C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/98 (2006.01) A61K 31/4412 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2547064
There is provided a compound of formula (I) wherein R1, R2a, R2b, R3a, R3b, R4, R5, R6, A, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competetive inhibitors of trypsin- like proteases, such as trombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e,g. conditions, such as thrombo-embolisms, where inhibition of trombin is required or desired, and/or conditions wherea anticoagulant thererapy is indicated).
L'invention concerne un composé de formule (I). Dans cette formule, R?1¿, R?2a¿, R?2b¿, R?3a¿, R?3b¿, R?4¿, R?5¿, R?6¿, A, G et L sont définis dans la description. Les composés de l'invention sont utiles en tant que promédicaments d'inhibiteurs compétitifs de protéases de type trypsine, notamment la thrombine et sont ainsi utiles, en particulier, dans le traitement de troubles dans lesquels l'inhibition de la thrombine est bénéfique (par exemple les troubles, comme les thrombo-embolismes, dans lesquels l'inhibition de la thrombine est nécessaire ou souhaitable, et/ou les troubles dans lesquels une thérapie d'anticoagulant est indiquée).
Berggren Kristina
Davidsson Oejvind
Fjellstroem Ola
Gustafsson David
Hanessian Stephen
Astrazeneca Ab
Fetherstonhaugh & Co.
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