New adenoviruses, nucleic acids coding therefor and their use

Details New adenoviruses, nucleic acids coding therefor and their use New adenoviruses, nucleic acids coding therefor and their use

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/005 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2515650

The invention relates to an adenovirus expressing a first protein which is selected among the group comprising an E1B protein and an E4 protein prior to a second protein that is selected among the group comprising an E1A protein, i.e. the order in which adenoviral genes are expressed is reversed. Said virus is used for the production of a medicament or for replication in cells. The inventive medicament is suitable especially for treating tumors that are multiresistant to cytostatic agents.

Adénovirus qui exprime une première protéine choisie dans le groupe comportant une protéine E1B et une protéine E4, avant une seconde protéine choisie dans le groupe comportant une protéine E1A.

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