New adjuvants on the basis of bisacyloxypropylcysteine...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/02 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) C07C 323/60 (2006.01) C08G 65/334 (2006.01)

Patent

CA 2628736

The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new conjugates of the bisacyloxycysteine type useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

La présente invention concerne de nouveaux adjuvants et l'utilisation de ceux-ci dans des compositions pharmaceutiques, comme dans des vaccins. En particulier, la présente invention concerne de nouveaux conjugués du type bisacyloxycystéine utiles comme adjuvants et/ou immunomodulateurs pour la vaccination prophylactique et/ou thérapeutique dans le traitement de maladies infectieuses, de maladies inflammatoires, de maladies auto-immunes, de tumeurs, d'allergies ainsi que pour le contrôle de la fécondité dans des populations humaines ou animales. Les composés sont particulièrement utiles non seulement comme adjuvants systémiques, mais aussi de préférence comme adjuvants pour la voie muqueuse. En plus, l'invention concerne l'utilisation de ceux-ci en tant qu'ingrédients actifs dans des compositions pharmaceutiques.

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