New alpha-glucosidase inhibitors from a natural source

Details New alpha-glucosidase inhibitors from a natural source New alpha-glucosidase inhibitors from a natural source

A - Human Necessities

61

K

A61K 31/36 (2006.01) A61K 31/16 (2006.01) A61P 3/06 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2505140

The present invention relates to a method for providing .alpha.-glucosidase inhibition to a subject by administering a pharmaceutical composition comprising a .alpha.-glucosidase inhibitory agent selected from pipataline (formula 1a), sesamin (formula 1b), pellitorine (Formula 1c), guineensine (Formula 1d) and brachystamide-B (formula 1e) having therapeutic application for diabetes mellitus, cancer, viral diseases such as hepatitis B and C, HIV, AIDS etc; also the invention provides a process for the isolation of said .alpha.-glucosidase inhibitory agent from the plant source Piper longum in significant yields.

L'invention concerne une méthode servant à provoquer l'inhibition d'.alpha.-glucosidase chez un individu par administration d'une composition pharmaceutique contenant un agent inhibiteur d'.alpha.-glucosidase sélectionné dans pipataline (formule 1a), sésamine (formule 1b), pellitorine (formule 1c), guinéensine (formule 1d) et brachystamide-B (formule 1e). Cette composition peut être utilisée pour traiter le diabète sucré, le cancer, des maladies virales, telles que l'hépatite B ou C, VIH, ou le SIDA. L'invention concerne également une méthode servant à isoler ledit agent inhibiteur d'.alpha.-glucosidase de la plante source <i>Piper longum</i> en quantités importantes.

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