C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 47/22 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2739673
The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions comprising these compounds are also provided.
La présente invention porte sur des composés qui ont des propriétés inhibant CYP450 et qui sont par conséquent utiles en tant que stimulants de certains médicaments, à savoir ils sont capables d'augmenter au moins l'une des variables pharmacocinétiques de certains médicaments lorsqu'ils sont co-administrés. L'invention porte en outre sur l'utilisation desdits composés en tant qu'agents améliorant la biodisponibilité de certains médicaments. L'invention porte également sur des procédés pour la préparation des composés de l'invention et sur des compositions pharmaceutiques comprenant ces composés.
Baumeister Judith Eva
Hache Geerwin Yvonne Paul
Hallenberger Beate Sabine
Jonckers Tim Hugo Maria
Sasaki Jennifer Chiyomi
Gowling Lafleur Henderson Llp
Tibotec Pharmaceuticals
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