New amidino derivatives and their use as thrombin inhibitors

Details New amidino derivatives and their use as thrombin inhibitors New amidino derivatives and their use as thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61P 7/02 (2006.01) C07D 207/16 (2006.01)

Patent

CA 2352054

There is provided compounds of formula (I), wherein R1, R x, Y, R y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

L'invention concerne des composés de la formule (I) dans laquelle R<1>, Rx, Y R<y>, n et B sont tels que définis dans le mémorandum descriptif. Ces composés sont utiles comme inhibiteurs de protéases apparentées à la trypsine, telles que la thrombine. Ils sont notamment utiles dans le traitement d'affections requérant l'inhibition de la thrombine (p. ex. la thrombose), ou comme anticoagulants.

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