New amidino derivatives and their use as thrombin inhibitors

Details New amidino derivatives and their use as thrombin inhibitors New amidino derivatives and their use as thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61P 7/02 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2294059

There is provided compounds of formula (I), wherein R1, R x, Y, R y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as antico-agulants.

L'invention concerne des composés de la formule (I) où R<1>, Rx, Y, R<y>, n et B ont la signification donnée dans la description. Ces composés sont utiles comme inhibiteurs compétitifs de protéases de type trypsine, tels que la thrombine, et plus particulièrement dans le traitement d'états nécessitant l'inhibition de la thrombine (p.ex. thrombose) ou comme anticoagulants.

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