C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/422 (2006.01) A61P 7/02 (2006.01) C07C 229/42 (2006.01) C07C 233/54 (2006.01) C07D 207/16 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2415383
There is provided compounds of formula I, wherein Y and R1 have meanings given in the description, and pharmaceutically acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
L'invention concerne des composés de formule (I), dans laquelle Y et R1 ont les significations décrites dans la description, ainsi que des dérivés (notamment des promédicaments) acceptables sur le plan pharmaceutique de ceux-ci. Ces composés et dérivés sont utilisés comme inhibiteurs compétitifs de protéases de type trypsine, tels que la thrombine, ou sont utilisés comme promédicaments de ceux-ci, et surtout utilisés, par conséquent, dans le traitement d'états pathologiques dans lesquels l'inhibition de la thrombine est nécessaire (par exemple la thrombose) ou ceux-ci sont utilisés comme agents anticoagulants.
Inghardt Tord
Svensson Arne
Astrazeneca Ab
Fetherstonhaugh & Co.
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