New amidinobenzylamine derivatives and their use as thrombin...

Details New amidinobenzylamine derivatives and their use as thrombin... New amidinobenzylamine derivatives and their use as thrombin...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/55 (2006.01) C07D 205/04 (2006.01) C07D 207/10 (2006.01) C07D 403/10 (2006.01)

Patent

CA 2355792

There is provided compounds of formula (I) wherein R1, R2 Y, R3 and R4 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

L'invention concerne des composés représentés par la formule (I), dans laquelle R?1¿, R?2¿, Y, R?3¿ et R?4¿ ont les notations données dans la description, ces composés étant utiles comme inhibiteurs compétitifs ou comme promédicaments de protéases du type trypsine, telle la thrombine, et en particulier dans le traitement d'affections dans lesquelles une inhibition de la thrombine est indiquée (p. ex. thrombose), ou comme anticoagulants.

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