New amino acid derivatives and their use as thrombin inhibitors

Details New amino acid derivatives and their use as thrombin inhibitors New amino acid derivatives and their use as thrombin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/695 (2006.01) A61K 38/05 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 207/22 (2006.01) C07D 211/60 (2006.01) C07D 211/78 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2255625

There is provided compounds of formula (I), wherein R1, R2, R3, Rx, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

L'invention concerne des composés de la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?x¿, Y, n et B ont les définitions données dans la description. Lesdits composés sont utiles en tant qu'inhibiteurs compétitifs de protéases de type trypsine, telles que la trombine, et en particulier dans le traitement d'états nécessitant une inhibition de la trombine (par exemple thrombose) ou en tant qu'anticoagulants.

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