C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2234610
The invention relates to new amino acid derivatives of general formula I R1 - R11 - A1 - A2 - NR2R3 (I) and the pharmaceutically acceptable salts thereof, wherein R1, A1, A2 , R2, R3 and R11 have the meanings given in the specification and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
L'invention concerne de nouveaux dérivés d'acide aminé de la formule générale (I) R<1>-R<11>-A<1>-A<2>-NR<2>R<3>, dans laquelle R<1>, A<1>, A<2>, R<2>, R<3> et R<11> ont la signification donnée dans la description. L'invention concerne également leurs sels pharmaceutiquement tolérables, leur production et leur utilisation. Les nouveaux composés sont de précieux antagonistes de la neurokinine (tachykinine).
Esser Franz
Giesler Guenther
Ignatow Hans-Peter
Jung Birgit
Schnorrenberg Gerd
Boehringer Ingelheim Kg
Fetherstonhaugh & Co.
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