A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/337 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 47/12 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2388613
A pharmaceutical formulation is provided for delivering paclitaxel in vivo comprising: water and micelles comprising paclitaxel and a pharmaceutically- acceptable, water-miscible solubilizer forming the micelles, the solubilizer selected from the group consisting of solubilizers having the general structures R1COOR2, R1CONR2, and R1COR2, wherein R1 is a hydrophobic C3-C50 alkane, alkene or alkyne and R2 is a hydrophilic moiety. The solubilizer is selected such that it does not have a pKa less than about 6.
La présente invention concerne une formulation pharmaceutique destinée à administrer du paclitaxel in vivo qui comprend de l'eau, et des micelles contenant du paclitaxel et un agent de solubilisation, formateur de micelles, soluble dans l'eau et acceptable sur le plan pharmaceutique. L'agent de solubilisation est choisi parmi des agents de solubilisation de structure générale R¿1?COOR¿2?, R¿1?CONR¿2?, et R¿1?COR¿2?, dans lesquelles R¿1? représente un alcane, un alcène ou un alcyne hydrophobe en C¿3?-C¿50?, et R¿2? représente une entité hydrophile. L'agent de solubilisation est choisi avec un pKa supérieur à environ 6.
Gore Ashok Y.
Joshi Rajashree
Rubinfeld Joseph
Shrotriya Rajesh
Borden Ladner Gervais Llp
Supergen Inc.
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