New anthraquinonic derivatives having an antitumor activity,...

Details New anthraquinonic derivatives having an antitumor activity,... New anthraquinonic derivatives having an antitumor activity,...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/47 (2006.01) C07D 221/08 (2006.01)

Patent

CA 2161318

Said derivatives have the general formula (I) and are; (I-A)4,6,7-trimethyl-5,8,8a,10a-tetrahydro-1H-1-azaanthracen- 2,9,10-trione: (I-B)2-ethoxy-3-methyl-1-azaanthracen-9,10- dione; (I-C)3-ethyl-1,8-dihydro-1H-1,8-diazaanthracen- 2,7,9,10-tetraone;(I-d)2-acethoxy-3-methyl-1,8- diazaanthracen-2,9,10-trione;(I-e)6-fluor-4-methyl-1H-1,8- diazaanthracen-2,9,10-trione;(I-g)4-methyl-5-(2-nitrophenyl)- 5,8-dihydro-1H-1,8-diazaanthracen-2,9,10-triona;(I-h)3,5- dimethyl-1,8-dihydro-1,8-diazaanthracen-2,7,9,10-tetraone;(I- i)3,6-difluor-1,8-diazaanthracen-9,10-dione;(I-j)6-methyl-3- phenyl-1H-1,8-diazaanthracen-2,9,10-trione;(I-k)3-fluor-4- methyl-1,4-dihydro-1-azaanthracen-9,10-dione;(I-l)3-fluor-1- azaanthracen-1,10-dione. Application as antitumor agents.

Les dérivés décrits répondent à la formule générale (I) et sont: (I-a) 4,6,7-triméthyle-5,8,8a,10a-tétrahydro-1H-1-azaanthracène-2,9,10-trione; (I-b) 2-éthoxy-3-méthyle-1-azaanthracène-9,10-dione; (I-c) 3-éthyle-1,8-dihydro-1H-1,8-diazaanthracène-2,7,9,10-tétraone; (I-d) 2-acétoxy-3-méthyle-1,8-diazaanthracène-2,9,10-trione; (I-e) 6-fluor-4-méthyle-1H-1,8-diazaanthracène-2,9,10-trione; (I-f) 6-diméthylamino-4-méthyle-1H-1,8-diazaanthracène-2,9,10-trione; (I-g) 4-méthyle-5-(2-nitrophényle)-5,8-dihydro-1H-1,8-diazaanthracène-2,9,10-trione; (I-h) 3,5-diméthyle-1,8-dihydro-1,8-diazaanthracène-2,7,9,10-tétraone; (I-i) 3,6-difluor-1,8-diazaanthracène-9,10-dione; (I-j) 6-méthyle-3-phényle-1H-1,8-diazaanthracène-2,9,10-trione; (I-k) 3-fluor-4-méthyle-1,4-dihodro-1-azaanthracène-9,10-dione; (I-l) 3-fluor-1-azaanthracène-1,10-dione. Application en tant qu'agents antitumoraux.

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