C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C12N 5/18 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2703825
The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of A.beta.8-X peptide, x being comprised from 11 to 42, and recognises neither A.beta.1-40 nor A.beta.1-42 and which presents a high affinity with respect to A.beta.8-X peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide A.beta.8-X.
La présente invention concerne un anticorps monoclonal qui se lie spécifiquement à la région N-terminale du peptide Aß8-X, x étant compris entre 11 et 42, qui ne reconnaît ni Aß1-40 ni Aß1-42 et qui présente pour le peptide Aß8-X une affinité élevée telle que déterminée par la formation d'un complexe immunologique entre l'anticorps monoclonal et le peptide Aß8-X.
Blanchard-Bregeon Veronique
Buee Luc
Delacourte Andre
Gompel Marie
Grognet Pierre
Goudreau Gage Dubuc
Innogenetics Nv
Inserm (institut National de La Sante Et de La Recherche Medical
Sanofi-Aventis
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