New antigen presenting cells, a process for preparing the...

Details New antigen presenting cells, a process for preparing the... New antigen presenting cells, a process for preparing the...

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 39/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2252505

The invention relates to monocytes derived antigen presenting cells (MD-APCs) characterized in that they have the following properties: they present on their surface: antigen CD14 and CD64 with a mean intensity of about 5 to about 200; antigen CD80 and CD86 with a mean intensity of about 20 to about 200; antigen CD40 and mannose receptor with a mean intensity of 50 to 500; they are substantially devoid of the surface antigens CD1a and CD1c; they present a phagocytosis property; they have the property of stimulating the proliferation of allogenic lymphocytes.

L'invention concerne des cellules présentant l'antigène dérivées des monocytes (MD-APC), caractérisées par les propriétés suivantes: elles présentent à leur surface les antigènes CD14 et CD64 avec une intensité moyenne comprise entre 5 et 200 environ, les antigènes CD80 et CD86 avec une intensité moyenne comprise entre 20 et 200 environ, l'antigène CD40 et le récepteur du mannose avec une intensité moyenne comprise entre 50 et 500; elles sont sensiblement dépourvues des antigènes de surface CD1a et CD1c; elles présentent une propriété de phagocytose; elles présentent la propriété de stimuler la prolifération de lymphocytes allogènes.

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