C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/35 (2006.01) A61K 39/04 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2698826
The present invention discloses new antigens of Mycobacterium avium subsp. paratuberculosis, antigenic compositions comprising at least two of said antigens, as well as epitopes, antibodies or hypervariable fragments thereof and nucleotide sequences coding for them. The present invention also concerns their use in diagnosis and/or vaccination against Mycobacterium avium subsp. paratuberculosis, in mammals, and in particular in cattle, but also in sheep and caprines. The invention also concerns their potential application in diagnosis and/or vaccination against Crohn's disease in human.
La présente invention concerne de nouveaux antigènes de Mycobacterium avium subsp. paratuberculosis, des compositions antigéniques contenant au moins deux desdits antigènes, ainsi que des épitopes, des anticorps ou des fragments hypervariables de ceux-ci ou des séquences nucléotidiques codant pour eux. La présente invention a également trait à leur utilisation dans le cadre du diagnostic de Mycobacterium avium subsp. paratuberculosis et/ou de la vaccination contre cette dernière, chez les mammifères, en particulier chez les bovins mais aussi chez les ovins et les caprins. L'invention se rapporte également à leur application potentielle dans le cadre du diagnostic de la maladie de Crohn ou de la vaccination contre cette dernière.
Georis Isabelle
Govaerts Marc
Huygen Christiane A. J.
Leroy Baptiste
Roupie Virginie
Cerva-Coda
Gowling Lafleur Henderson Llp
Institut Scientifique de Sante Publique
Universite de Mons
Universite de Mons-Hainaut
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