New antiviral peptides which prevent the binding of the...

Details New antiviral peptides which prevent the binding of the... New antiviral peptides which prevent the binding of the...

C - Chemistry, Metallurgy

07

K

C07K 14/01 (2006.01)

Patent

CA 2703368

New antiviral peptides interfering the binding of the virus to DLC8 A high number of pathogenic agents of viral origin use the dynein based intracellular transport machinery at some point of their infective cycie. The present invention consists of a new antiviral therapy consisting in the inhibition of viral infections produced by those virus that use the dynein system by mechanisms of interference mainly by preventing the interaction between the viral protein and the cellular DLC8 protein. The present invention discloses for the first time the blocking of the function of this interaction by peptides whose sequence comprises or consists of the totality or a partial sequence of the viral protein corresponding to the binding domain with DLC8.

L'invention concerne de nouveaux peptides antiviraux qui interfèrent avec la liaison du virus à DLC8. Un grand nombre d'agents pathogènes d'origine virale utilisent le système de transport intracellulaire fondé sur les dynéines à un moment de leur cycle infectieux. La présente invention concerne une nouvelle thérapie antivirale qui consiste en l'inhibition des infections virales produites par ces virus qui utilisent le système des dynéines par des mécanismes d'interférence, principalement en empêchant l'interaction entre la protéine virale et la protéine DLC8 cellulaire. La présente invention décrit pour la première fois le blocage de la fonction de cette interaction par des peptides dont la séquence comprend ou consiste en la totalité ou une séquence partielle de la protéine virale qui correspond au domaine de liaison avec DLC8.

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