New antiviral substituted pyrimidinedione homocarbocyclic...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/60 (2006.01) A61K 31/505 (2006.01) A61K 31/695 (2006.01) C07D 239/54 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2217026

The present invention relates to novel compounds of the general formula (I): Image wherein R1, R2, and R3 represents independently a hydrogen or halogen atom or a C1-C10 alkyl, C1-C10 thioalkyl, C3-C8 optionally substituted cycloalkyl, unsaturated alkyl, substituted alkyl hydroxyl or aryl hydroxyl, C1-C10 alkylamine, nitro, C1-C4, lower ester, C1-C4 lower alkoxy or C1- C4 lower thioalkoxy group; Z represents an oxygen, sulfur atom or carbon atom or a carbonyl group; X represents an oxygen or sulfur atom; n represents an integer of 1-3; and (sub)cycloalk(en)yl represents Image in which Image represents Image in which R4 and R5 represents independently a hydrogen atom or a hydroxymethyl, protected hydroxymethyl benzyl, substituted carbonyl, substituted alkylsulfonyl or arylsulfonyl or substituted silyl group, and pharmaceutically acceptable salts thereof. The compounds according to the invention are useful as antiviral agents for treating acquired immunodeficiency syndromes.

Nouveau composé répondant à la formule générale (I), ses sels pharmaceutiquement acceptables, procédé de préparation de dérivés de ce type, et compositions pharmaceutiques les renfermant à titre d'ingrédients actifs. Dans la formule générale (I), R1, R2 et R3, indépendamment les uns des autres, représentent un atome d'hydrogène, un atome d'halogène, alkyle C1-10, thioalkyle C1-10, cycloalkyle C3-8 éventuellement substitué, alkyle insaturé, alkylhydroxyle ou arylhydroxyle substitué, alkylamine C1-10, nitro, ester inférieur C1-4, alcoxy inférieur C1-4 ou thioalcoxy inférieur C1-4; Z représente un atome d'oxygène, un atome de soufre, un atome de carbone ou un groupe carbonyle; X représente un atome d'oxygène ou un atome de soufre; n est un entier compris entre 1 et 3; et (sous)cycloalkyle ou (sous)cycloalcényle représente (a) ou (b), où (a) représente (c), (d), (e) ou (f), où R4 et R5, indépendamment l'un de l'autre, représentent un atome d'hydrogène, hydroxyméthyle, hydroxyméthyle protégé, benzyle, carbonyle substitué, alkylsulfonyle ou arylsulfonyle substitué, silyle substitué ou analogue.

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