C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/15 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 211/58 (2006.01) C07D 211/62 (2006.01) C07D 211/64 (2006.01) C07D 211/66 (2006.01) C07D 295/145 (2006.01) C07D 317/60 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01) C07D 471/10 (2006.01)
Patent
CA 2218096
The invention relates to new arylglycinamide derivatives of general formula I (see formula I) and the pharmaceutically acceptable salts thereof, wherein R1 and R2 together with the N to which they are bound form a ring of the formula (see formula II) wherein p is 2 or 3 and X denotes oxygen, N(CH2)n R6 or CR7R8, and R3, R4, R5, R6, R7, R8, Ar and n have the meanings given in the specification, and the preparation and use thereof. The new compounds are valuable neurokinin (tachykinin)-antagonists.
La présente invention concerne de nouveaux dérivés d'arylglycinamides de formule générale (I) ainsi que leurs sels acceptables en pharmacie, R<1> et R<2> formant, avec le N auquel ils sont liés, un composé cyclique de formule (II) dans laquelle p est égal à 2 ou 3 et X représente soit l'oxygène, soit N(CH2)nR<6>, soit CR<7>R<8> et R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, Ar et n ont les notations indiquées dans la description. L'invention porte aussi sur la fabrication et l'emploi de ces composés. Ces composés nouveaux sont de précieux antagonistes de la neurokinine (tachykinine).
Briem Hans
Dollinger Horst
Esser Franz
Jung Birgit
Schnorrenberg Gerd
Boehringer Ingelheim Kg
Fetherstonhaugh & Co.
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