C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 225/10 (2006.01) A61K 31/135 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07C 217/36 (2006.01) C07D 295/112 (2006.01) C07D 333/32 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2048626
-28- Summary New aryloxy-alkylamine derivatives of the general formula I Image in which A signifies a benzene or thiophene ring, R and R1, independently of one another, each hydrogen, alkyl, halogen, CF3 or alkoxy, R2 alkyl, cycloalkyl, alkenyl, alkynyl, alkaryl or saturated or usnaturated aliphatic or aromatic acyl, R3 and R4 in each case hydrogen, alkyl, alkenyl, alkynyl or cycloalkyl with, in each case, up to 8 C-atoms, whereby R3 and R4 can be the same or different but are not simultaneously hydrogen or R3 and R4, together with the nitrogen atom connecting them, form a 5- to 7-membered saturated ring or a saturated heterocyclic ring which can possibly contain an oxygen or nitrogen atom as a further heteroatom in the ring, whereby an additional nitrogen atom can be substituted by an alkyl radical with up to 3 C-atoms, and their acid-addition salts possess interesting pharmaceutical properties and are especially suitable as anti-arrhythmics.
Greier Gerhard
Lotz Bernhard
Laevosan-Gesellschaft Mbh
Swabey Ogilvy Renault
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