New arylpiperazinylalkyl-3 (2h)-pyridazinones

Details New arylpiperazinylalkyl-3 (2h)-pyridazinones New arylpiperazinylalkyl-3 (2h)-pyridazinones

C - Chemistry, Metallurgy

07

D

C07D 237/14 (2006.01) A61K 31/501 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2310873

A description is given of new arylpiperazinylalkyl-3(2H)-pyridazinones of general formula (I) and their preparation and their addition salts with pharmaceutically acceptable acids, (see formula I) in which R1 is a methyl or phenyl radical, R2 is a hydrogen atom or a methyl radical, n takes values between 2 and 4, and R3 is a naphthyl radical or a phenyl radical, which are substituted by a radical such as methoxyl, trifluoromethyl and chlorine. The compounds present affinity for serotonin 5HT 1A and 5HT2 receptors and for dopamine D2 receptors, and can be useful as antipsychotics.

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