New attenuated strain of the virus causing the porcine...

Details New attenuated strain of the virus causing the porcine... New attenuated strain of the virus causing the porcine...

C - Chemistry, Metallurgy

12

N

C12N 7/08 (2006.01) A61K 39/12 (2006.01) C12N 5/06 (2006.01) C12N 7/00 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2216436

The invention relates to a new attenuated strain (CNCM Institut Pasteur I- 1642) of the virus causing the porcine disease known as porcine reproductive respiratory syndrome (PRRS), as well as to a process for the attenuation and replication of said strain by the use of a new clone obtained from monkey kidney cells MA-104 (CNCM Institut Pasteur I-1643). Due to its innocuousness for the suines and due to its high immunogenic activity, said new attenuated strain provides for the production of vaccines and diagnostic means which make possible an early diagnosis of PRRS and an efficient preventive treatment of said disease.

L'invention décrit une nouvelle souche atténuée (CNCM Institut Pasteur I-1642) du virus provoquant la maladie porcine connue sous le nom de syndrome respiratoire et reproductif porcin (PRRS), ainsi qu'un procédé d'atténuation et de réplication de ladite souche au moyen d'un nouveau clone obtenu à partir de cellules de rein de singe MA-104 (CNCM Institut Pasteur I-1643). Compte tenu de son innocuité pour les suidés et de son intense activité immunogénique, cette nouvelle souche atténuée permet d'obtenir des vaccins et des moyens de diagnostic qui rendent possible un diagnostic précoce du PRRS et un traitement préventif efficace de cette maladie.

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