New azetidine derivatives as neurokinin receptor antagonists...

Details New azetidine derivatives as neurokinin receptor antagonists... New azetidine derivatives as neurokinin receptor antagonists...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 25/00 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2612133

The application relates to new piperazine- or morpholine-substituted azetidine derivatives of formula I. These compounds are antagonists at the neurokinin receptor and can be used for the treatment of gastrointestinal diseases. The application also relates to processes for the preparation of the compounds and to intermediates in said preparation.

La présente invention porte sur de nouveaux dérivés d'azétidine substitués par une pipérazine ou une morpholine de formule (I). Ces composés sont des antagonistes au niveau du récepteur de la neurokinine et peuvent être utilisés dans le traitement des maladies gastro-intestinales. Cette invention porte également sur des procédés de préparation des composés, ainsi que sur des intermédiaires utilisés dans cette préparation.

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