New benzamide derivatives as bradykinin antagonists

Details New benzamide derivatives as bradykinin antagonists New benzamide derivatives as bradykinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) C07D 207/26 (2006.01) C07D 211/16 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/38 (2006.01) C07D 211/44 (2006.01) C07D 211/58 (2006.01) C07D 211/62 (2006.01) C07D 211/68 (2006.01) C07D 211/76 (2006.01) C07D 219/06 (2006.01)

Patent

CA 2667387

The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I), wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.

La présente invention concerne de nouveaux dérivés de benzamide phénylsulfamoyle représentés par la formule générale (I) dans laquelle R1-R5 et Z désignent des éléments décrits dans les revendications, ainsi que des antipodes optiques ou des racémates et/ou des sels et/ou des hydrates et/ou des solvates de ceux-ci. Ces dérivés sont des antagonistes sélectifs de la bradykinine B1. L'invention concerne également des procédés destinés à la production de ces composés, des compositions pharmaceutiques contenant ces composés et leur utilisation dans le traitement ou la prévention d'états douloureux et inflammatoires.

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