New benzimidazole derivatives

Details New benzimidazole derivatives New benzimidazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/31 (2006.01) A61K 31/41 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 3/00 (2006.01) A61P 19/00 (2006.01) A61P 21/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2734034

The invention is concerned with novel benzimidazole derivatives of Formula (I) wherein A, n and R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds act on Farnesyl X receptor (FXR) and against cholesterol and lipid illnesses, diabetes, obesity, psoriasis, cancer, osteoporosis, Parkinson's and Alzheimer's disease.

L'invention porte sur de nouveaux dérivés de benzimidazole représentés par la Formule (I), dans laquelle A, n et R1 à R7 sont tels que définis dans la description et dans les revendications, ainsi que sur des sels et esters physiologiquement acceptables de ceux-ci. Ces composés agissent sur le récepteur Farnésoïde X (FXR) et contre des maladies liées au cholestérol et aux lipides, le diabète, l'obésité, le psoriasis, le cancer, l'ostéoporose, la maladie de Parkinson et la maladie d'Alzheimer.

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