New benzimidazolone-, benzoxazolone-, or benzothiazolone...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 235/26 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2349616

The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.

L'invention concerne des agents de modulation de canaux ioniques. Elle concerne, plus particulièrement, un catégorie particulière de composés chimiques qui se sont avérés utiles en tant que modulateurs des canaux de SK¿Ca?, IK¿Ca? et BK¿Ca?. Dans d'autres aspects, l'invention concerne l'utilisation de ces agents de modulation des canaux de SK/IK/BK pour la préparation de médicaments, ainsi que des compositions pharmaceutiques contenant ces agents de modulation des canaux de SK/IK/BK. Ces agents sont utiles pour le traitement ou le soulagement de maladies et d'états associés aux canaux de SK/IK/BK.

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