New betamimetics having a long-lasting activity, processes...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 265/36 (2006.01) A61K 31/4184 (2006.01) A61K 31/536 (2006.01) A61P 11/00 (2006.01) C07D 235/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2405745

The invention relates to betamimetics of the general formula (1), wherein R1 represents a group (a), where R3 represents benzyl which can optionally be substituted by methoxy, R4 represents hydrogen, or R3 and R4 conjointly represent a -CO-CH2-O- bridge, whereby the carbonyl group of this bridge is bonded to the nitrogen; R2 represents a group selected from (b) and (c), whereby R5 represents dimethylamino, methoxy or butoxy, X represents a nitrogen or a carbon, R6 represents methoxyphenyl if X is nitrogen, or if X is carbon, an annellated phenyl ring likewise linked to X. The invention also relates to a method for the production of said betamimetics and to their use as medicaments.

L'invention concerne des bêta-mimétiques de formule (1), dans laquelle R?1¿ représente un groupe (a) où R?3¿ représente benzyle éventuellement substitué par méthoxy ; R?4¿ représente hydrogène ; ou R?3¿ et R?4¿ représentent conjointement un pont -CO-CH¿2?-O-, le groupe carbonyle de ce pont étant lié à l'azote ; R?2¿ représente un reste sélectionné parmi (b) et (c) où R?5¿ représente diméthylamino, méthoxy ou butoxy ; X représente azote ou carbone ; R?6¿ représente méthoxyphényle, lorsque X représente azote, ou un noyau phényle annelé également lié à X, lorsque X représente carbone. L'invention concerne également des procédés de production de ces composés ainsi que l'utilisation de ces derniers comme médicament.

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