C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/506 (2006.01) A61K 31/551 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C07D 211/58 (2006.01) C07D 243/08 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2700691
The invention is concerned with novel biaryl derivatives of Formula (I), wherein Formula (A), m, R1, R2, R3, X1, X2 and X3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
La présente invention concerne de nouveaux dérivés de biaryle de formule (I), dans laquelle la formule (A), m, R1, R2, R3, X1, X2 et X3 sont tels que définis dans la description et les revendications, ainsi que leurs sels pharmaceutiquement acceptables. Ces composés sont des antagonistes du récepteur CCR-2, du récepteur CCR-5 et/ou du récepteur CCR-3 et peuvent être utilisés comme médicaments.
Aebi Johannes
Binggeli Alfred
Green Luke
Hartmann Guido
Maerki Hans P.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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