New bis-benzimidazoles

Details New bis-benzimidazoles New bis-benzimidazoles

C - Chemistry, Metallurgy

07

D

C07D 235/20 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2346040

Bis-benzimidazole compounds of general formula (I) in which R1, R2, R3 and R4 are hydrogen, hydroxy or halogen, R5 and R8 are hydrogen, or (C1-C4)-alkyl,R6 and R7 are hydrogen, or (C1-C6)-alkyl, hydroxy, halogen, or (C1-C6)-alkoxy, R9, R10 and R11 are hydrogen, halogen, nitro, cyano or trifluoromethyl, and A is a non-aromatic 5-7-membered N-heterocycle, etc, process for their preparation and their use for treating diseases associated with tryptase activity including allergic, inflammatory and related immunological diseases, in particular asthma, allergic rhinitis, allergic conjunctivitis and allergic dermatitis.

L'invention porte sur des composés bis-benzimidazole de la formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont un hydrogène, un hydroxy ou un halogène, R?5¿ et R?8¿ sont un hydrogène, ou (C¿1?-C¿4?)-alkyl, R?6¿ et R?7¿ sont un hydrogène, ou (C¿1?-C¿6?)-alkyl, hydroxy, halogène, ou (C¿1?-C¿6?)-alcoxy, R?9¿, R?10¿ et R?11¿ sont un hydrogène, halogène, nitro, cyano ou trifluorométhyle, et A est un N-hétérocycle non aromatique de 5 à 7 éléments, etc. L'invention porte également sur un procédé de préparation et d'utilisation de ces composés dans le traitement de pathologies associées à l'activité tryptasique telles que les maladies allergiques, inflammatoires et immunologiques, notamment l'asthme, la rhinite allergique, la conjonctivite allergique et la dermatite allergique.

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