New bis-platinum complexes as chemotherapeutic agents

C - Chemistry – Metallurgy – 07 – F

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C07F 15/00 (2006.01) A61K 31/28 (2006.01) A61K 31/555 (2006.01)

Patent

CA 2065271

A bis(platinum) complex having structure (I), wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are ha- lide, sulphate, phoshate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate primary or secon- dary amine, sulfoxide, phosphine, pyridine-type nitrogen and the like; preferably, there is at least one Pt-anion bond on each Pt molecule; and A is a diamine or polyamine. Complexes of trans geometry [PtX2(L)(L')] where at least L is a planar ligand such as pyridine but preferably quinoline and L' may be amine, sulfoxide or substituted sulfoxide and X is a chloride, nitrate or carboxylate. A process for obtaining bis(platinum) complexes where the two platinum coordination spheres may contain different ligands in each sphere and where the geometry of each platinum coordination sphere may be the same or different.

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