C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/282 (2006.01) A61P 35/00 (2006.01) C07C 211/14 (2006.01)
Patent
CA 2260971
Bis-platinum(II) complexes with polyamine ligands, the method of making bis- platinum(II) complexes and the use thereof for the treatment of tumors in mammals, are disclosed. The method of making the polyamine ligands, and the use of a new compound VII(c) as an intermediate in the synthesis of polyamine ligands, are also disclosed.
Cette invention se rapporte à des complexes de bis-platine (II) comportant des ligands polyamine, à un procédé de fabrication de complexes de bis-platine (II) et à l'utilisation de ces complexes pour traiter des tumeurs chez les mammifères. L'invention se rapporte également au procédé de fabrication des ligands polyamine et à l'utilisation d'un nouveau composé VII(c) utilisé en tant qu'intermédiaire dans la synthèse des ligands polyamine.
Di Domenico Roberto
Farrell Nicholas P.
Menta Ernesto
Spinelli Silvano
F. Hoffmann-La Roche Ag
Long And Cameron
Virginia Commonwealth University
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