C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) A61K 31/28 (2006.01) C07C 231/02 (2006.01) C07C 231/12 (2006.01) C07C 231/14 (2006.01) C07C 233/56 (2006.01) C07C 237/10 (2006.01) C07C 273/18 (2006.01) C07C 275/14 (2006.01) C07C 277/08 (2006.01) C07C 279/12 (2006.01) C07C 303/34 (2006.01) C07C 307/06 (2006.01) C07C 279/24 (2006.01)
Patent
CA 2234638
Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of these complexes for the treatment of tumors in mammals, are disclosed. The bis- platinum(II) Complexes are of formula (I): Image wherein: X, Y, and Z ligands are selected from the group consisting of ammonia, chloride, bromide, iodide or carboxylate of formula R-COO-C1-C4, in which R is a (C1-C4)alkyl group, with the proviso that two of X, Y, and Z are ammonia, the other being selected among chloride, bromide, iodide, and carboxylate R-COO-; n and m, which can be the same or different, are an integer from 2 to 8; p is the integer 1 or 2; the bifunctional ligand A is a polymethylene derivative; Q- p is a suitable counter- ion, comprising enantiomers and diastereoisomers thereof. The method of making the polymethylene derivatives, is also disclosed.
Cette invention se rapporte à des complexes de bis-platine (II) comportant des dérivés de polyméthylène, à un procédé de fabrication de ces complexes et à l'utilisation de ces complexes pour traiter des tumeurs chez les mammifères. L'invention se rapporte également au procédé de fabrication des dérivés de polyméthylène.
Di Domenico Roberto
Farrell Nicholas P.
Menta Ernesto
Spinelli Silvano
Boehringer Mannheim Italia S.p.a.
F. Hoffmann-La Roche Ag
Long And Cameron
Virginia Commonwealth University
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