New butyric esters with antiproliferative activity and the...

C - Chemistry – Metallurgy – 08 – B

Patent

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C08B 37/00 (2006.01) A61K 31/513 (2006.01) A61K 31/675 (2006.01) A61K 31/716 (2006.01) A61K 31/728 (2006.01) A61K 31/737 (2006.01) A61K 33/24 (2006.01) A61K 36/04 (2006.01) A61P 35/00 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2272720

The present application describes total or partial butyric esters of polysaccharides as novel compounds; the number of hydroxyl groups esterified with butyric residues per each glycosidic monomer is preferably higher than 0.001; the application also describes the process of preparation of said esters, their use in therapy as antiproliferative agents, and pharmaceutical compositions containing them.

La présente invention concerne des esters butyriques complets ou partiels de polysaccharides qui sont de nouveaux composés. Le nombre de groupes hydroxyl estérifiés comportant des radicaux butyriques est, pour chaque monomère glycosidique, de préférence supérieur à 0,001. L'invention concerne également le procédé de préparation de ces esters, leur utilisation thérapeutique en tant qu'agents antiprolifératifs et des compositions pharmaceutiques les contenant.

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