New candida albicans kre9 and uses thereof

Details New candida albicans kre9 and uses thereof New candida albicans kre9 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/40 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2314611

The present invention relates to an isolated DNA which codes for a gene essential for cell wall glucan synthesis of Candida albicans, wherein the gene is referred to as CaKRE9, wherein the sequence of the DNA is as set forth in Fig. 1. The present invention relates to antifungal in vitro and in vivo screening assays for identifying compounds which inhibit the synthesis, assembly and/or regulation of .beta.1,6-glucan. There is also disclosed an in vitro method for the diagnosis of diseases caused by fungal infection in a patient.

L'invention concerne un ADN isolé codant pour un gène essentiel à la synthèse de glucane de la paroi cellulaire de Candida albicans, ce gène étant désigné CaKRE9, la séquence de cet ADN étant illustrée par la figure 1. Elle concerne des méthodes de criblage antifongique in vitro et in vivo servant à identifier des composés inhibant la synthèse, l'assemblage et/ou la régulation de .beta.1,6-glucane. Elle concerne également un procédé in vitro servant à diagnostiquer des maladies provoquées par une infection fongique chez un malade.

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