New candida albicans kre9 and uses thereof

Details New candida albicans kre9 and uses thereof New candida albicans kre9 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C07K 14/40 (2006.01) C12Q 1/18 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2218446

The present invention relates to an isolated DNA which codes for a gene essential for cell wall glucan synthesis of Candida albicans, wherein the gene is referred to as CaKRE9, wherein the sequence of the DNA is as set forth in Fig. 1. The present invention relates antifungal in vitro and in vivo screening assays for identifying a compound which inhibit the synthesis, assembly and/or regulation of .beta.1,6-glucans. There is also disclosed an in vitro method for the diagnosis of diseases caused by fungal infection in a patient.

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