New caspase homologue

Details New caspase homologue New caspase homologue

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335099

Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. This invention relates to the identification of a new murine caspase and its human homologue. The new molecules are most related to human/murine caspase-2 and human caspase-9 and possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a very short prodomain. Northern blot analysis revealed that mRNA expression of the new caspase is predominant in skin.

Les caspases sont des protéases spécifiques du cystéinyl aspartate dont bon nombre jouent un rôle central dans l'apoptose. La présente invention concerne l'identification d'une nouvelle caspase murine et de son homologue humain. Les nouvelles molécules sont principalement liées à la caspase-2 humaine/murine et à la caspase-9 humaine, possèdent tous les résidus d'acide aminé typiques des caspases associées à la catalyse, y compris la séquence QACRG, et contiennent aucun prodomaine ou un prodomaine très court. Le transfert de type Northern a révélé que l'expression de l'ARN messager de la nouvelle caspase prédomine dans la peau.

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