New cationic and polycationic amphiphiles, reagents...

C - Chemistry – Metallurgy – 07 – K

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C07K 5/06 (2006.01) A61K 9/127 (2006.01) C07C 219/08 (2006.01) C07C 237/08 (2006.01) C07C 271/22 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2224566

New cationic and polycationic amphiphiles are capable of building aggregates with macromolecules, in particular DNA or RNA. Also disclosed is their insertion into prokaryotic and eucaryotic cells. Compounds with a spermyl- dioleoyloxypropyl structure have proven to be particularly advantageous.

L'invention concerne de nouveaux amphiphiles cationiques ou polycationiques susceptibles de former des agrégats avec des macromolécules, notamment l'ADN ou l'ARN. L'invention concerne également leur introduction dans des cellules procaryotes ou eucaryotes. On a découvert que les composés de structure spermyle-dioléoyloxypropyle sont particulièrement avantageux.

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