New cephalotaxanes, their method of preparation and their...

Details New cephalotaxanes, their method of preparation and their... New cephalotaxanes, their method of preparation and their...

C - Chemistry, Metallurgy

07

D

C07D 491/20 (2006.01) A61K 31/55 (2006.01) A61P 35/02 (2006.01) C07D 209/00 (2006.01) C07D 223/00 (2006.01) C07D 267/00 (2006.01) C07D 313/00 (2006.01) C07D 317/00 (2006.01) C07D 487/20 (2006.01) C07D 498/20 (2006.01) C07D 498/22 (2006.01)

Patent

CA 2426103

The present invention concerns a compound of formula (I) wherein: W represents O or NH, Q represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), R1 is H, OH, OMe, O-(C1- C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2-C30)-alkenyl, O-(C3-C30)-cycloalkyl or null and R2 is H or OH, or R1, R2 form together -O-, R3=R4=OMe or R3 and R4 form together -OCH2O-, R is H, C1-C30alkyl or O-protecting group and R6 represents an unbranched or branched, saturated or unsaturated or aromatic, cyclic or acyclic or heterocyclic hydrocarboned radical containing 1 to 30 carbon atoms including or not heteroatom(s), or R and R6 form together -CMe2-, n is 0 to 8, R5 is H, OH, OMe, O-(C1-C30)-alkyl, O-aryl-(C1-C30)-alkyl, O-(C2- C30)-alkenyl, O-(C3-C30)-cycloalkyl or O-aryl, the doted line is null or forms a double bond depending on the meaning of R1. It also concerns their methods of preparation and their use in treatment of cancers, leukemias, parasites and as reversal agents of harringtonines.

L'invention concerne un composé représenté par la formule (I) dans laquelle: W représente O ou NH, Q représente un radical hydrocarboné ramifié ou non ramifié, saturé ou insaturé ou aromatique, cyclique, acyclique ou hétérocyclique contenant 1 à 30 atomes de carbone, y compris ou non des hétéroatomes, R?1¿ représente H, OH, OMe, O-(C¿1?-C¿30?)-alkyle, O-aryl-(C¿1?-C¿30?)-alkyle, O-(C¿2?-C¿30?)-alcényle, O-(C¿3?-C¿30?)-cycloakyle ou zéro et R?2¿ représente H ou OH, ou R?1¿ et R?2¿ représentent ensemble -O-, R?3¿ = R?4¿ = OMe et R?3¿ et R?4¿ représentent -OCH¿2?O-, R représente H, alkyle C¿1?-C¿30? ou un groupe O-protecteur et R?6¿ représente un radical hydrocarboné ramifié ou non ramifié, saturé ou unsaturé ou aromatique, cyclique ou acyclique ou hétérocyclique contenant 1 à 30 atomes de carbone, y compris ou non des hétéroatomes, ou R et R?6¿ représentent -CMe¿2?-, n est 0 à 8, R?5¿ représente H, OH, O Me, O-(C¿1?-C¿30?)-alkyle, O-aryl-(C¿1?-C¿30?)-alkyle, O-(C¿2?-C¿30?)-alcényle, O-(C¿3?-C¿30?)-cycloalkyle ou O-aryle, la ligne pointillée représentant zéro ou constituant une double liaison en fonction de la signification de R?1¿. Elle concerne également leurs procédés de préparation et leur utilisation dans le traitement de cancers, leucémies ou parasitoses et en tant qu'agents d'inversion des harringtonines.

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