New chemokine expressed in eosinophils

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2217025

The present invention relates to novel nucleotide and amino acid sequences for a novel C-C chemokine initially found in a cDNA library from blood cells of an individual having Hypereosinophilic Syndrome. The present invention also provides for antisense molecules to the nucleotide sequences which encode EEC, expression vectors for the production of purified EEC, antibodies capable of binding specifically to EEC, hybridization probes or oligonucleotides for the detection of EEC-encoding nucleotide sequences EEC, diagnostic tests for chemokine activation based on EEC-encoding nucleic acid molecules and antibodies capable of binding specifically to EEC.

La présente invention porte sur un nouveau nucléotide et des séquences d'acides aminés pour une nouvelle chimioquine C-C rencontrée à l'origine dans une banque d'ADN complémentaire à partir de globules sanguins d'un individu atteint du syndrome de granulocytose éosinophile. Elle porte également sur des molécules antisens par rapport à des séquences nucléotides qui codent pour la chimioquine EEC, des vecteurs d'expression destinés à la production de chimioquine EEC purifiée, des anticorps capables de se fixer de manière spécifique à la chimioquine EEC, des sondes d'hybridation ou des oligonucléotides permettant la détection de la chimioquine EEC au moyen de séquences nucléotides codant pour la chimioquine EEC, de tests diagnostiques d'activation de chimioquine d'après des molécules d'acide nucléique codant pour la chimioquine EEC et des anticorps capables de se fixer de manière spécifique à la chimioquine EEC.

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