C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/18 (2006.01) A61K 31/215 (2006.01) A61K 31/335 (2006.01) C07C 69/00 (2006.01) C07C 69/736 (2006.01) C07D 493/10 (2006.01) C07D 493/20 (2006.01) C07D 493/22 (2006.01)
Patent
CA 2057917
The present invention relates to a new class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions thereof, processes for preparing the same, and uses thereof. Compounds of the invention are prepared by combining phorbol related diterpenes and homovanillic acid analogs via esterification at the exocyclic hydroxy group for the diterpene. Examples of these compounds include 20- homovanillyl-mezerein and 20-homovanillyl-12- deoxyphorbol-13-phenyl-acetate. These compounds having a variable spectrum of activities for capsaicin-like responses are represented by the following formulas I to IV: (see formula I, II, III) (see formula IV,) wherein R1 in formulas (I)-(IV) represents (see formula V,VI) with the proviso that in formula (II), R' is not (see formula VII) R3 and R4 are not H at the same time. The compounds are useful in therapeutic compositions for desensitizing a subject animal.
Blumberg Peter M.
Szallasi Arpad
Gowling Lafleur Henderson Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
LandOfFree
New class of compounds having a variable spectrum of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with New class of compounds having a variable spectrum of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and New class of compounds having a variable spectrum of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1429277