A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/24 (2006.01) C07K 14/59 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2181711
The invention is concerned with a mixture of isoforms of a glycoprotein with follicle stimulating activity, a pharmaceutical composition comprising such isoforms as well as a method to induce follicular growth and maturation. Better results were obtained if a pharmaceutical composition with a relatively high proportion of basic isoforms were administered in controlled hyperstimulation. More oocytes could be retrieved and a lower dosage as well as a shorter treatment period sufficed.
L'invention concerne un mélange d'isoformes d'une glycoprotéine à activité folliculo-stimulante, une composition pharmaceutique contenant ce type d'isoformes, ainsi qu'un procédé permettant d'induire la croissance et la maturation folliculaires. On a enregistré de meilleurs résultats dans les cas où la composition pharmaceutique comportait une proportion relativement importante d'isoformes basiques et avait été administrée en hyperstimulation régulée, ce qui avait permis de récupérer davantage d'ovocytes, à un dosage moindre et sur une période de traitement moins étendue.
de Leeuw Renato
Rombout Ferdinand
Akzo Nobel Nv
de Leeuw Renato
Fetherstonhaugh & Co.
Rombout Ferdinand
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