C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/20 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2294746
There are provided novel compounds of formula (I) including their 3,4- dihydropyrimidine tautomer form, wherein R1, R2, R3, R4, R5, X and n are as defined in the specification, and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are antagonists of N-type neuronal calcium channels useful in the treatment of cerebrovascular ischaemia and pain.
L'invention porte sur de nouveaux composés de la formule (I) qui comprennent leur forme 3,4-dihydropyrimidine tautomère, formule dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, X et n étant tels que définis dans la demande, ainsi que des isomères optiques et leurs composés racémiques, et leurs sels pharmaceutiquement acceptables. L'invention porte également sur leurs procédés de préparation, les compositions les contenant et leur utilisation en thérapie. Ces composés sont des antagonistes des canaux calciques neuronaux de type N utiles dans le traitement de l'ischémie cérébrovasculaire et de la douleur.
Downs Eileen S.
Michne William F.
Pierson M. Edward Jr.
Astra Aktiebolag
Fetherstonhaugh & Co.
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