New compounds

Details New compounds New compounds

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 38/05 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2312431

There are provided compounds of formula (I), wherein R1, R2, R3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

L'invention concerne les composés de la formule (I) où R<1>, R<2>, R<3>, Rx, Y, n et B ont la signification donnée dans la description. Ces composés sont utiles comme inhibiteurs compétitifs de protéases de type trypsine, telles que la thrombine, et notamment dans le traitement d'états exigeant l'inhibition de la thrombine (p.ex. thrombose) ou bien comme anticoagulants.

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