C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2723981
The invention provides named compounds of formula (I), wherein R4 is a N- sustituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.
L'invention porte sur des composés représentés par la formule (I), dans laquelle R4 est une quinuclidine substituée en N (I), sur des compositions pharmaceutiques les contenant et sur un procédé de fabrication de ces compositions pharmaceutiques. L'invention porte également sur leur utilisation en thérapie pour le traitement d'affections à médiation par les récepteurs muscariniques M3, telles qu'une bronchopneumopathie chronique obstructive.
Bull Richard James
Ford Rhonan Lee
Mather Andrew Nigel
Mete Antonio
Skidmore Elizabeth Anne
Astrazeneca Ab
Fetherstonhaugh & Co.
Pulmagen Therapeutics (synergy) Limited
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