C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/24 (2006.01) A61K 31/135 (2006.01) C07B 59/00 (2006.01) C07C 255/61 (2006.01) C07C 323/45 (2006.01) C07D 239/545 (2006.01) C07D 263/04 (2006.01) C07D 407/04 (2006.01)
Patent
CA 2114085
Abstract New compounds useful as anti-cancer agents and as agents useful for the treatment of illnesses arising due to an abnormally elevated cell proliferation rate, having the general formula (I): Image wherein: L is hydrogen or deuterium; R may be alkyl, alkenyl, alkynyl, having from 1-20 C atoms OR1, wherein R1 is H or alkyl with 1-4 carbon atoms, COR2 wherein R2 is OH or OR5 wherein R5 is alkyl with 1-4 carbon atoms, NR'R" wherein R' and R" may be the same or different and may be H or alkyl with 1-4 carbon atoms; R3XR4 wherein R3 and R4 may be the same or different and may be alkyl with 1-20 carbon atoms and X may be O, NH, S; substituted or unsubstituted phenyl, unsubstituted or substituted heterocyclic ring, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-20 C atoms, all said groups may be further substituted. Z and Y, which may be the same or different, are H, D, alkyl with 1-4 carbon atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-4 C atoms, or OR wherein R may be H or alkyl with 1-4 carbon atoms, or CF3, - CR1=O, wherein R1 may be H, D, alkyl with 1-4 carbon atoms, or OR2, wherein R2 may be H or an alkyl with 1-4 carbon atoms, -CN, R3XR4, wherein R3 and R4 may be the same or different and may be alkyl with 1-20 carbon atoms and X may be O, NH or S; and pharmaceutically acceptable salts thereof.
Borretzen Bernt
Dornish John Michael
Larsen Rolf Olaf
Moen Vidar
Oftebro Reidar
Fetherstonhaugh & Co.
Norsk Hydro A.s.
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