New compounds

Details New compounds New compounds

C - Chemistry, Metallurgy

07

D

C07D 407/04 (2006.01) A61K 31/375 (2006.01) C07B 59/00 (2006.01) C07D 317/14 (2006.01) C07D 339/06 (2006.01)

Patent

CA 2087656

20876-9 28477-9 Abstract New compounds having the general formula I Image wherein L may be H or D; Y may be CN or Image wherein A may be H, D, alkyl with 1-4 carbon atoms, OR wherein R is X or alkyl with 1-4 carbon atoms, or CR1R2R3 wherein R1, R2 and R3 are the same or different and are H or alkyl with 1-4 carbon atoms; Z is H, D, Y or alkyl with 1-4 C-atoms, halogen, nitro, amino, monoalkyl amino or dialkyl amino wherein the alkyl groups have 1-4 C atoms, or OR wherein R may be H or alkyl with 1-4 C atoms, or CR4R5R6 wherein R4 R5 and R6 may be the same or different and may be H or F; X1 and X2 may be the same or different and may be OR, NR1R2 or SR, wherein R, R1 and R2 may be the same or different and may be alkyl having 1-22 carbon atoms which may be branched or straight chained and/or may be further substituted; or X1 and X2 may together with the carbon atom to which they are bound form a cyclic acetal, thioacetal, dithiane, aminal, oxazolidine or thiazolidine; and pharmaceutically acceptable salts thereof. The compounds are useful as anti-cancer agents and as agents useful for the treatment of illnesses arising due to an abnormally elevated cell-proliferation.

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