New compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2629984

The present invention relates to new mGluR1 and mGluR5 receptor subtype preferring ligands of formula (I); wherein Y represents a subtituent selected from hydrogen, methyl, fluoro, chloro, bromo, methoxy; Z is hydrogen or methyl; R is an optionally substituted heteroaryl, and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of pathological conditions which require the modulation of mGluR1 and mGluR5 receptors such as neurological disorders, psychiatric disorders, acute and chronic pain and neuromuscular dysfunctions of the lower urinary tract.

Nouveau sous-type des récepteurs mGluR1 et mGluR5 ayant une préférence pour les ligands de formule (I), dans laquelle Y représente un substituant qui peut être hydrogène, méthyle, fluoro, chloro, bromo, méthoxy ; Z est hydrogène ou méthyle ; R est hétéroaryle éventuellement substitué, et/ou sels et/ou hydrates et/ou solvates correspondants. Par ailleurs, procédés de production correspondants, compositions pharmaceutiques renfermant le produit décrit, et leur utilisation en thérapie et/ou pour la prévention d'états pathologiques nécessitant la modulation des récepteurs mGluR1 and mGluR5, du type troubles neurologiques, troubles psychiatriques, douleur aiguë et chronique et dysfonctionnements neuromusculaires des voies urinaires inférieures.

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