New compounds and their compositions having...

C - Chemistry – Metallurgy – 07 – C

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C07C 203/04 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 31/36 (2006.01) C07C 219/34 (2006.01) C07C 235/56 (2006.01) C07C 235/64 (2006.01) C07D 317/62 (2006.01)

Patent

CA 2235996

Compounds, or their compositions, of general formula: A - X1 - NO2 or their salts, used as medicaments, wherein: A = R(COX)t; t = 0 or 1; X = O; X0 = X; R being (a) wherein: R1, R2 and R3 are alkyls; X1 is a bivalent linking group chosen among -YO wherein Y is chosen among a linear or when permissible branched C1-C20 alkylene, a cycloalkylene having 5 to 7 carbon atoms optionally substituted; (b) wherein n is an integer from 1 to 6, R2a being H, CH3; r = 0 or 1.

Ces composés ou leurs compositions, de la formule générale A - X1 - NO2, ou des sels de ceux-ci, sont utilisés en tant que médicaments. Dans cette formule A = R(COX)t, t = 0 ou 1, X = O, XO = X, R répondant à la formule (a) dans laquelle R1, R2 et R3 représentent des alkyles, X1 représente un groupe de liaison bivalent choisi entre -YO, où Y est choisi dans le groupe constitué par alkylène C1-C20 linéaire, ou le cas échéant ramifié, et cycloalkylène possédant 5 à 7 atomes de carbone éventuellement substitués, ou (b) où n est un nombre entier compris entre 1 et 6, R2a représente H, CH3, et r vaut 0 ou 1.

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