New compounds, methods for their preparation and use thereof

Details New compounds, methods for their preparation and use thereof New compounds, methods for their preparation and use thereof

C - Chemistry, Metallurgy

07

C

C07C 233/54 (2006.01) A61K 31/196 (2006.01) A61K 31/24 (2006.01) A61K 31/40 (2006.01) A61P 19/02 (2006.01) C07C 321/28 (2006.01) C07C 321/30 (2006.01) C07D 207/06 (2006.01) C07D 211/14 (2006.01)

Patent

CA 2552942

Compounds of formula (I), for clinical treatment of autoimmune diseases, inflammatory diseases, organ transplant rejection and malignant neoplasia. A pharmaceutical composition comprising a compound of formula (I) in an amount giving a daily dosage of from 0.005 mg/kg to 10 mg/kg body weight, in particular from 0.025 mg/kg to 2 mg/kg body weight.

L'invention concerne des composés représentés par la formule (I). Ces composés sont utilisés dans le traitement clinique de maladies auto-immunes, de maladies inflammatoires, de rejets de transplantation et de néoplasie maligne. L'invention concerne également une composition pharmaceutique comprenant un composé représenté par la formule (I) en quantité donnant un dosage journalier d'environ 0,005 mg/kg à 10 mg/kg du poids corporel, notamment entre 0,025 mg/kg à 2 mg/kg du poids corporel.

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