C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 313/02 (2006.01) A61K 31/185 (2006.01) A61K 31/195 (2006.01) C07C 313/04 (2006.01)
Patent
CA 2448518
Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro or an oxo group;R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates and the stereoisomers thereof, with the exception of the racemate of (3-amino-2- hydroxypropyl)sulphinic acid.The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.
L'invention concerne de nouveaux composés de la formule (I) dans laquelle R¿1? représente hydrogène; R¿2? représente hydroxy, fluoro ou un groupe oxo; R¿3? représente hydrogène; R¿4? représente hydrogène; ainsi que leurs sels, solvates et stéréoisomères pharmaceutiquement acceptables, à l'exception du racémate de l'acide (3-amino-2-hydroxypropyl)sulfinique. Les composés sont utiles en thérapie, notamment pour le traitement de maladies à reflux. L'invention concerne également leurs procédés de préparation, les intermédiaires dudit procédé ainsi que des compositions pharmaceutiques contenant lesdits composés thérapeutiquement actifs de même que l'utilisation desdits composés actifs en thérapie.
Fitzpatrick Kevin
Geiss William
Lehmann Anders
Sunden Gunnel
von Unge Sverker
Astrazeneca Ab
Fetherstonhaugh & Co.
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